20 janvier 2016 ~ 0 Commentaire

Foam Granulation part 3

single screw extruder

A scholarly analysis at pilot-scale flow rates compared foamed-binder addition and direct liquid-injection on granulation. A methylcellulose binder was employed at two concentrations, 6% and 11%, relative to a-lactose monohydrate powder. Two screws were analyzed in the work to produce differing axial compression characteristics with changing flow level: one with a single pair of mixing factors delivering lower axial compression and a second with two pairs in series to supply a far more restrictive flow route and higher axial compression. The granule properties from the analysis showed that comparable sizes and intragranular porosity were achieved by either method, provided appropriate conditions were used. The decreased requirement for liquid along the way was a similar finding compared to that found with high-shear batch mixers.

Wet granulation in twin screw extrusion machinery has several key advantages over conventional strategies, but to advance found in acceptance for GMP production, its operations need to be better comprehended and challenges regarding process stableness must be solved. Constant foam granulation is a fresh, robust strategy that solves the procedure surging issues that relate with poor powder wetting by regular, liquid-addition methods. The superior spreading tendency of foam in granulation, versus the instant soaking aspect of liquids, produces extra uniformly wetted powders and increases the overall lubricity of the procedure, which benefits dress yourself in behavior of the minimizes and machine dissipative heating of the product. With comparable particle real estate to conventional wet granulation, foam granulation gives formulators better flexibility in achieving production goals.

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